Detailed compatibility can be found here.
The SL3s is Vais Technology's second-generation solution for controlling your SIRIUS tuner (Not Included) aftermarket Satellite Radio tuner directly through your vehicle's audio system.
It is compatible with Lexus "SAT-ready" audio systems whether or not they are equipped with a navigation system, and whether they have a SAT button or not. The SL3s seamlessly integrates your SIRIUS receiver into your OEM audio system. This means touch screen/steering wheel control, easy-to-read, expanded 16-character display, and browsing by channel name, channel number, category or presets. It also means outstanding sound quality in your car not possible through cassette adapters, FM transmitters or FM modulators.
The unique, direct plug-and-play connection technology of the SL3s doesn't affect factory-installed components such as 6-disc CD changer or CD/DVD changer. When you connect the SL3s to your audio system, the vehicle recognizes it as an additional OEM SAT device. And since the SoundLinQ system utilizes the factory audio system connectors, it installs easily without compromising your vehicle's warranty. SL3s comes preprogrammed in SAT mode and compatible with '05-'13 Lexus "SAT-ready" vehicles only. Channel and Song information can be displayed on the Radio LCD or Navigation screen.